[Alpha blockaders--first or second line antihypertensive agents?].

P Lund-Johansen; I Hjermann; B M Iversen; E Thaulow

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PubMed · 8096657

[Alpha blockaders--first or second line antihypertensive agents?].

P Lund-Johansen·I Hjermann·B M Iversen·E Thaulow

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Abstract

Alpha-receptor blockers reduce blood pressure by blocking of the alpha 1-receptors in the smooth muscle cells in the arteriolar walls. The heart pump function is not disturbed. Most studies have shown that the alpha-receptor blockers induce a reduction in plasma-triglycerides and an increase in the ratio between HDL- and LDL-cholesterol. They do not interfere with the metabolism of electrolytes, glucose or uric acid and have no negative effect on pulmonary function. Although long-term use does not induce a permanent increase in heart rate, some patients respond to initial therapy with faster heart rate and palpitations. The alpha-receptor blockers should not be used in patients with coronary heart disease if the patient is not on chronic beta-blockade. When these precautions are followed, the alpha-blockers can be used as first-line treatment--just like ACE-inhibitors and calcium-antagonists.

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Adrenergic alpha-Antagonists Antihypertensive Agents Contraindications Drug Evaluation Humans Journal Article Review

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P Lund-Johansen, I Hjermann, B M Iversen, E Thaulow. 1993-02-28. [Alpha blockaders--first or second line antihypertensive agents?].. https://pubmed.ncbi.nlm.nih.gov/8096657/

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