Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis.

P P Sfikakis; J Tesar; H Baraf; R Lipnick; G Klipple; G C Tsokos

doi:10.1006/clin.1993.1100

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Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis.

P P Sfikakis·J Tesar·H Baraf·R Lipnick·G Klipple·G C Tsokos

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Abstract

In view of recent data demonstrating increased expression of intercellular adhesion molecule-1 (ICAM-1) in the skin of patients with systemic sclerosis (SSc) we studied whether levels of soluble ICAM-1 (s-ICAM-1) shed into the circulation are increased in patients with this disorder. We also compared blood levels of s-ICAM-1 in SSc with those in systemic lupus erythematosus (SLE) and we investigated any possible association of s-ICAM-1 with soluble IL-2 receptor (s-IL 2R) levels, the latter being considered as a marker of lymphocyte activation. Patients with SSc had increased levels of sICAM-1 compared with healthy control subjects (mean +/- SEM, 587 +/- 34 versus 373 +/- 27 ng/ml, P < 0.0001). Patients with diffuse rapidly progressive disease had the highest s-ICAM-1 levels. No association was observed between the extent of skin or internal organ involvement and s-ICAM-1 levels. Patients with digital ulcers had significantly elevated s-ICAM-1, but not s-IL 2R, levels. No correlation was detected between individual s-ICAM-1 and S-IL 2R levels in SSc patients. These novel findings suggest that circulating s-ICAM-1 levels may be a useful marker of endothelial activation in SSc; however, further studies are needed to determine the role of ICAM-1 in the pathogenesis of this disorder.

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Adolescent Adult Aged Cell Adhesion Molecules Child Female Gastrointestinal Diseases Humans Intercellular Adhesion Molecule-1 Male Middle Aged Receptors, Interleukin-2 Scleroderma, Systemic Solubility Journal Article Research Support, Non-U.S. Gov't

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P P Sfikakis, J Tesar, H Baraf, R Lipnick, G Klipple, G C Tsokos. 1993. Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis.. https://doi.org/10.1006/clin.1993.1100

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