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PubMed · 8102002

[Cytokines and immune response].

L Pelletier·B Bellon·P Druet
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Abstract

This review paper briefly describes the principal cytokines involved in immune response, and in particular their role in some of its key-steps: antigen presentation; activation, proliferation and differentiation of CD4+ T cell subsets; antibody response by B cells; manifestations of hypersensitivity. The role played by cytokines in cytotoxic T cell (CTL) differentiation and in T cell-mediated suppression phenomena is also discussed. It seems that the auxiliary CD4+ memory cells secrete either IL-2 and interferon gamma (Th1) or IL-4 and IL-5 (Th2). It has recently been suggested that cytotoxic/suppressor CD8+ cells can also be divided into cells that secrete interferon gamma and no IL-4 (CTL) and cells that secrete IL-4 and IL-5 (suppressor T cells). The reciprocal regulatory effects of these cell populations through these interleukins is also discussed.

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AnimalsCD4-Positive T-LymphocytesCell DifferentiationCell DivisionCytokinesImmunity, CellularInterleukinsEnglish AbstractJournal ArticleReview

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L Pelletier, B Bellon, P Druet. 1993-03-01. [Cytokines and immune response].. https://pubmed.ncbi.nlm.nih.gov/8102002/

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