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PubMed · 8104038

Lysyl oxidase copper-talon complex: a model.

C J Krebs·S A Krawetz
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Abstract

The translated primary amino-acid sequences from human genomic and human, rat and mouse lysyl oxidase cDNAs were subjected to computer comparison. This revealed a highly-conserved primary structure and similar computer-predicted secondary structures. A prototypical lysyl oxidase structural model was reconciled with the known physical, chemical and biological properties. Analysis of the post-translationally-modified and proteolytically-processed mature enzyme model revealed a copper coordination complex that may be contained as part of the active site. This integral copper coordination complex resembles a talon. The proposed model should facilitate the elucidation of these and other structural and functional relationships within the lysyl oxidase molecule.

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4-HydroxycoumarinsAmino Acid SequenceAnimalsCopperHumansMiceModels, MolecularMolecular Sequence DataProtein Structure, SecondaryProtein-Lysine 6-OxidaseRatsSequence AlignmentSoftwareJournal ArticleResearch Support, Non-U.S. Gov't

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C J Krebs, S A Krawetz. 1993-09-03. Lysyl oxidase copper-talon complex: a model.. https://doi.org/10.1016/0167-4838(93)90056-w

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