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PubMed · 8104095

Dopamine D3 receptor: basic and clinical aspects.

J C Schwartz·D Levesque·M P Martres·P Sokoloff
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Abstract

The recently discovered dopamine D3 receptor can be considered as a D2-like receptor: it is encoded by a gene comprising several introns; it is both an autoreceptor and a postsynaptic receptor, well recognized by antipsychotics. It differs, however, from the D2 receptor by a much more discrete expression, mostly in few limbic brain areas, e.g. shell of nucleus accumbens, islands of Calleja, and a considerably higher affinity for dopamine. Two association studies preliminarily suggest that the homozygotes for a D3 receptor gene polymorphism display twofold higher risk of schizophrenia, whereas several linkage studies led to inconclusive results.

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Amino Acid SequenceAnimalsAntipsychotic AgentsHumansMolecular Sequence DataReceptors, DopamineReceptors, Dopamine D2Receptors, Dopamine D3Journal ArticleReview

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BibTeXRIS

J C Schwartz, D Levesque, M P Martres, P Sokoloff. 1993. Dopamine D3 receptor: basic and clinical aspects.. https://doi.org/10.1097/00002826-199308000-00002

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