Oncogene elements within an endogenous retrovirus.

K A Whartenby; R A Insel; S M Freeman; P Keng; G N Abraham

PubMed · 8105657

Oncogene elements within an endogenous retrovirus.

K A Whartenby·R A Insel·S M Freeman·P Keng·G N Abraham

Abstract

The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.

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Base Sequence Blotting, Southern Cell Cycle Cell Line, Transformed Genes, Viral Genes, ras Humans Molecular Sequence Data Oncogenes Polymorphism, Restriction Fragment Length Retroviridae Transcription, Genetic Tumor Cells, Cultured Journal Article Research Support, U.S. Gov't, P.H.S.

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K A Whartenby, R A Insel, S M Freeman, P Keng, G N Abraham. Oncogene elements within an endogenous retrovirus.. https://pubmed.ncbi.nlm.nih.gov/8105657/

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