Genetically modified animals and immunodeficiency.

R S Yeung; J Penninger; T W Mak

doi:10.1016/0952-7915(93)90042-q

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Genetically modified animals and immunodeficiency.

R S Yeung·J Penninger·T W Mak

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Abstract

Mouse strains with defined genetic defects engineered by the method of targeted gene disruption and homologous recombination have furthered our understanding of immune functions at the single gene level. More importantly, these mutant 'gene knockout' mice are powerful in vivo tools to dissect the complex mechanisms of lymphocyte development and function, complementing our broadening knowledge of congenital and acquired human immunodeficiencies.

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Animals B-Lymphocytes CD4-Positive T-Lymphocytes DNA Nucleotidyltransferases Histocompatibility Antigens Class I Histocompatibility Antigens Class II Immunologic Deficiency Syndromes Integrases Major Histocompatibility Complex Mice Mice, Transgenic Receptors, Antigen, T-Cell Recombinases Signal Transduction T-Lymphocytes, Regulatory Journal Article Review

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R S Yeung, J Penninger, T W Mak. 1993. Genetically modified animals and immunodeficiency.. https://doi.org/10.1016/0952-7915(93)90042-q

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