Group sequential testing in clinical trials with multivariate observations: a review.

J W Lee

doi:10.1002/sim.4780130202

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Group sequential testing in clinical trials with multivariate observations: a review.

J W Lee

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Abstract

Most group sequential testing procedures assume that each patient has only one response. Thus interim test statistics have independent increments. In many clinical trials, however, a response variable is measured at each follow-up visit. In this article, I review some recently developed group sequential methods for repeated measures and for other types of multivariate responses. Six parametric methods and three non-parametric methods are included. My review focuses on the comparison of the assumptions made and the applications of each of these methods.

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Clinical Trials as Topic Data Interpretation, Statistical Linear Models Multivariate Analysis Survival Analysis Journal Article Research Support, U.S. Gov't, P.H.S.Review

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J W Lee. 1994-01-30. Group sequential testing in clinical trials with multivariate observations: a review.. https://doi.org/10.1002/sim.4780130202

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