Eicosanoids in synaptic transmission.

D Piomelli

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PubMed · 8124731

Eicosanoids in synaptic transmission.

D Piomelli

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Abstract

Arachidonic acid is released from membrane phospholipids in a receptor-dependent manner when neurons or glial cells are stimulated with neurotransmitters, hormones, or growth factors. The released fatty acid can be metabolized in brain tissue by three enzymatic pathways--cyclooxygenase, lipoxygenase, and cytochrome P450--giving rise to a series of biologically active products, the eicosanoids. Intracellular actions of these lipids include regulation of membrane ion channels, protein kinases, and ion pumps, thus suggesting a role as neuronal second messengers. In addition, the eicosanoids may be released into the extracellular space and interact with high affinity, G protein-coupled receptors on neurons and glial cells. Acting through these two distinct and complementary modes of action, the eicosanoids may participate in several forms of neuromodulation and synaptic plasticity.

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Animals Eicosanoids Humans Synapses Synaptic Transmission Journal Article Review

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D Piomelli. 1994. Eicosanoids in synaptic transmission.. https://pubmed.ncbi.nlm.nih.gov/8124731/

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