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PubMed · 8131848

Human complement component C8. Molecular basis of the beta-chain polymorphism.

G Dewald·S Hemmer·M M Nöthen
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Abstract

The beta-chain of human complement component C8 exhibits a structural genetic polymorphism: using isoelectric focusing two major allotypes can be identified (C8B B ('basic') and C8B A ('acidic')). In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA-->GGA) and demonstrate that the resulting amino acid substitution (Arg-->Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.

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Amino Acid SequenceBase SequenceComplement C8DNA, ComplementaryHeterozygoteHomozygoteHumansIsoelectric FocusingMolecular Sequence DataPolymerase Chain ReactionPolymorphism, GeneticJournal Article

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G Dewald, S Hemmer, M M Nöthen. 1994-03-07. Human complement component C8. Molecular basis of the beta-chain polymorphism.. https://doi.org/10.1016/0014-5793(94)80140-1

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