PubMed · 8132183
Occlusive patch method for skin sensitization in guinea pigs: the Buehler method.
Abstract
Currently, the European Community is in the process of discussing the details of how to conduct various protocols for safety assessment. Additionally, there is a desire that these protocols be harmonized internationally. This presentation attempts to describe the critical and non-critical parameters of the protocol for detecting potential contact allergens in the guinea pig and also discusses some controversial issues. It is also emphasized that the identification of a test material as a potential sensitizer is only the first step in the risk-assessment exercise.
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E V Buehler. 1994. Occlusive patch method for skin sensitization in guinea pigs: the Buehler method.. https://doi.org/10.1016/0278-6915(94)90169-4
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