PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 8141715

Issues raised by GUSTO.

H White
View original source ↗Export metadata ↓

Abstract

The GUSTO trial raises several questions including the role of heparin in thrombolysis. The need for intravenous versus subcutaneous heparin with streptokinase (SK) has not been clarified in this trial. It is more likely that the superiority of tissue plasminogen activator (t-PA) was due to its accelerated administration rather than the accompanying heparin. Despite the improvement in survival, much is still to be achieved in obtaining optimal reperfusion rates.

Explore related subjects

HeparinHumansInjections, IntravenousInjections, SubcutaneousMyocardial InfarctionRandomized Controlled Trials as TopicStreptokinaseThrombolytic TherapyTissue Plasminogen ActivatorComparative StudyJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H White. 1993. Issues raised by GUSTO.. https://doi.org/10.1111/j.1445-5994.1993.tb04752.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Thermally reversible pluronic/heparin nanocapsules exhibiting 1000-fold volume transition.

Novel Pluronic/heparin composite nanocapsules that exhibit a thermally responsible swelling and deswelling behavior were synthesized. Pluronic F-127 preactivated with p-nitrophenyl chloroformate at its two terminal hydroxyl groups was dissolved in a methylene chloride phase. The organic phase was dispersed in an aqueous phase containing heparin. At an organic/aqueous interface, Pluronic-cross-linked heparin nanocapsules were produced. They exhibited a 1000-fold volume transition (ca. 336 nm at 25 degrees C; ca. 32 nm at 37 degrees C), and a reversible swelling and deswelling behavior when the temperature was cycled between 20 and 37 degrees C. The reversible volume transition of Pluronic nanocapsules was caused by micellization and demicellization of cross-linked Pluronic polymer chains within the nanocapsule structure in response to temperature. The morphological characters were investigated with transmission electron microscopy and small angle neutron scattering. Pluronic/heparin nanocapsules had an aqueous fluid-filled hollow interior with a surrounding shell layer below the critical temperature, but they became a collapsed core/shell structure similar to that of Pluronic micelles above it.

Heparin↗