PubMed · 8145065
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P B Swan. 1994. Cornelia Kennedy (1881-1969).. https://doi.org/10.1093/jn%2F124.4.455
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Fluorine has come to be recognized as a key element in materials science: in heat-transfer agents, liquid crystals, dyes, surfactants, plastics, elastomers, membranes, and other materials. Furthermore, many fluorine-containing biologically active agents are finding applications as pharmaceuticals and agrochemicals. Progress in synthetic fluorine chemistry has been critical to the development of these fields and has led to the invention of many novel fluorinated molecules as future drugs and materials. As a result of the electronic effects of fluorine substituents, fluorinated substrates and reagents often exhibit unusual and unique chemical properties, which often make them incompatible with established synthetic methods. Thus, the problem of how to control the unusual properties of compounds with fluorine substituents deserves much attention, so as to promote the design of facile, efficient, and environmentally benign methods for the synthesis of valuable organofluorine targets.
Henri Braconnot was born in Commercy in 1780. When he was 13 years old, he was bound apprentice in the pharmacy of Graux in Nancy. He remained here for two years, learning pharmacy, chemistry and botany. When the army called him, his position in Strasbourg allowed him to study. After it, he came to Paris and learned in some schools, particularly the Ecole gratuite de pharmacie. Returned in Nancy, forever, in 1802, he was then named as the chairman of the botanical garden and a member of the academy of the town, and he began his results in plant chemistry. He worked almost until his death that occurred in January 1855. Braconnot's work is essentially devoted to chemistry. His name is attached to the extractive principles of vegetables. Some orientations of his research are: plant acids, fats, extractive compounds that may have conduct him to alkaloïds, sugar obtained from saw-dust and rages, other organic plant chemicals, nitration of cellulose, and some others such as colours chemistry, hydrology, physiological chemistry, toxicology, mineralogy. He was never received as an apothecary, but pharmacy has always considered that he belonged to it.
Combinatorial chemistry has become a major focus of research activity in the pharmaceutical industry for development new therapeutic compounds. The same techniques could be potentially applied to benefit agricultural and food research. This article reviews the various procedures used in combinatorial chemistry, outlines some of the strengths and limitations of the various methods, and proposes potential areas in agriculture and food that could be benefited by this technology. These areas include developing new antimicrobial agents, antioxidants, and other additives, creating antigen-binding molecules for the detection or removal of food pathogens or toxicants, engineering food proteins and enzymes for specific functions, and modifying biosynthetic pathways for the production of novel natural products.