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Alcohol misuse and the predisposing environment.

Abstract

In recent years, the aetiology of alcohol misuse has come to be conceptualised in terms of risk factor models. Risk can emanate from a number of sources ranging from the genetic to the sociostructural. This chapter reviews the major environmental risk factors under two broad headings--those that affect the availability of the agent and those that affect the vulnerability of the host. The former include a variety of economic, social and physical factors such as price, advertising and licensing laws. The latter include broad socioeconomic and sociocultural factors, as well as interpersonal influences such as family, peers, employment and stress. Practitioners (as distinct from policy-makers) concerned with prevention and treatment of alcohol misuse can most effectively intervene at the interpersonal level, and the paper concludes with a discussion of the implications for clinical practice of the research reviewed in this domain.

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BibTeXRIS

D M Gorman. 1994. Alcohol misuse and the predisposing environment.. https://doi.org/10.1093/oxfordjournals.bmb.a072882

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Misalignment between ultra-processed status and 'better for you' claims on premix alcohol products.

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Antioxidant constituents in distillation residue of Awamori spirits.

Constituents in a distillation residue of Awamori (millet spirits) and their antioxidant activity are investigated in this study. The supernatant of the distillation residue obtained by centrifugation was partitioned with n-hexane, chloroform, ethyl acetate, and n-butanol against water to afford the corresponding solubles. Among them, n-hexane and chloroform solubles showed higher antioxidant potency than l-ascorbic acid by the bleomycin-Fe method. In chloroform solubles, seven cyclic dipeptides were identified along with ethyl 2-pyrrolidione-5-carboxylate, tyrosol, and ethyl p-hydoroxyphenyllactate. Antioxidant activity of ethyl p-hydoroxyphenyllactate was 4.2 times that of l-ascorbic acid, whereas cyclic dipeptides showed activity 0.89-1.29 times as strong as that of l-ascorbic acid. On the other hand, scavenging effect of cyclic dipeptides against O(2)(-.) and OH(.) by using electron spin resonance was also investigated. In the results, cyclo(l-Ile-l-Pro) showed significantly strong inhibitory effect against OH(.) (95.4% at 2.5 x 10-3 M) and cyclo(l-Phe-l-Pro), cyclo(l-Pro-l-Val), and cyclo(l-Leu-l-Pro) inhibited OH(.) 64.9, 54.1, and 51.0%, respectively, whereas alpha-tocopherol showed 37.7% inhibition, though only a few cyclic dipeptides weakly inhibited O(2)(-.).

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