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PubMed · 8162432

Capturing host plasmin(ogen): a common mechanism for invasive pathogens?

R Lottenberg·D Minning-Wenz·M D Boyle
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Abstract

Plasmin is a potent enzyme that can dissolve blood clots and degrade extracellular matrix proteins. A number of pathogenic bacteria produce plasminogen activators. Many of these organisms can also bind plasmin(ogen) to surface receptors and protect the active enzyme from physiological inhibition. Cell-surface localization of plasmin may be a common mechanism used by bacteria to facilitate movement through normal tissue barriers.

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BacteriaBacterial InfectionsCell MembraneFibrinolysinHumansModels, BiologicalPlasminogenJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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R Lottenberg, D Minning-Wenz, M D Boyle. 1994. Capturing host plasmin(ogen): a common mechanism for invasive pathogens?. https://doi.org/10.1016/0966-842x(94)90340-9

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