PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 8163714

Computer-assisted evaluation of adverse events using a Bayesian approach.

K L Lanctôt·C A Naranjo
View original source ↗Export metadata ↓

Abstract

The differential diagnosis of idiosyncratic adverse drug reactions (ADRs) is complex because for each adverse event there are many possible drug and nondrug causes. Recently efforts have been made to computerize causality assessment methods. A new computerized, user-friendly diagnostic aid for Bayesian assessment of adverse drug events (MacBARDI-Q&A) is described. This computer program performs a differential diagnosis on cutaneous reactions suspected of being drug-induced. The authors' results indicate that development of a valid, simple and user-friendly computerized procedure for evaluating adverse drug events is possible. The ongoing development and application of MacBARDI-Q&A and other similar programs should improve the evaluation of putative adverse drug reactions.

Explore related subjects

AnticonvulsantsBayes TheoremDiagnosis, Computer-AssistedDrug HypersensitivityEvaluation Studies as TopicHumansSulfonamidesSurveys and QuestionnairesJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

K L Lanctôt, C A Naranjo. 1994. Computer-assisted evaluation of adverse events using a Bayesian approach.. https://doi.org/10.1002/j.1552-4604.1994.tb03978.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor.

Medical therapy for essential tremor (ET), a common movement disorder, is often inadequate. We performed a double-blind placebo-controlled randomized trial to evaluate the efficacy and tolerability of zonisamide (ZNS), an antiepileptic agent, in treating ET. Twenty patients (mean age, 60 +/- 15 years) with ET were randomized to receive ZNS or placebo. ZNS was initiated at a dosage of 100 mg/day and escalated to 200 mg/day at day 14. Patients were evaluated by accelerometry and the Fahn-Tolosa-Marin (FTM) rating scale at baseline and days 14 and 28, as well as the Clinical Global Impression (CGI-C) scale at day 28. At endpoint, subjects assigned to ZNS were taking a mean dosage of 160 +/- 50 mg/day. There were no significant improvements in the FTM total score or its subsections. Tremor amplitude as assessed by accelerometry significantly improved in the ZNS group compared to the placebo group at endpoint relative to baseline (-0.50 +/- 0.72 vs. 0.30 +/- 0.79 m/s(2); P = 0.03). On the CGI-C, 60% (n = 6) of patients in the ZNS group felt that their tremor was unchanged, while the remaining patients felt that their tremor was "minimally improved." Thirty percent (n = 3) of patients taking ZNS discontinued the study due to side effects (fatigue, headache, paresthesias) while taking 100 mg per day. ZNS did not provide significant improvements in clinical rating scales at study endpoint compared to placebo and was only modestly well tolerated. ZNS was effective in reducing tremor amplitude as measured by accelerometry.

Anticonvulsants↗