[Quantitative risk assessment: extrapolation methods from high doses to low doses].

W Szymczak; B Barański

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PubMed · 8170379

[Quantitative risk assessment: extrapolation methods from high doses to low doses].

W Szymczak·B Barański

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Abstract

Two methods of linear extrapolation from high to low doses were discussed. The first method depended on fitting a particular model (multistage, logistic) from the experimental data and then on extrapolating from the point on the dose-response curve to the lowest positive dose level employed. The linearized multistage model of carcinogenesis was used in the second method--the results obtained were highly conservative.

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Animals Dose-Response Relationship, Drug Linear Models Logistic Models Models, Biological Neoplasms, Experimental Polychlorinated Dibenzodioxins Rats Risk Factors Journal Article Research Support, Non-U.S. Gov't

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W Szymczak, B Barański. 1994. [Quantitative risk assessment: extrapolation methods from high doses to low doses].. https://pubmed.ncbi.nlm.nih.gov/8170379/

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