B cell antigen receptors.

M Reth

doi:10.1016/0952-7915(94)90026-4

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B cell antigen receptors.

M Reth

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Abstract

Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen receptor is functionally divided into the ligand-binding immunoglobulin (Ig) molecule and the signal-transducing Ig-alpha/Ig-beta heterodimer. This knowledge has been exploited to design variant antigen receptors which combine both functions in a single molecule.

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Amino Acid Sequence Animals B-Lymphocytes Humans Immunoglobulin G Immunoglobulin M Molecular Sequence Data Receptors, Antigen, B-Cell Signal Transduction Journal Article Review

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M Reth. 1994. B cell antigen receptors.. https://doi.org/10.1016/0952-7915(94)90026-4

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