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PubMed · 8177449

[Immunostimulation in heart surgery: thymostimulin. Preliminary data].

M Maccherini·G Davoli·G Sani·F Miraldi·G Gotti·M Toscano
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Abstract

The immunodepressive effect of surgical procedures is well known. Immunotherapy with thymic hormones has used a long time to prevent surgical immunitary damage. In cardiac surgery, we can observe a hard immunitary depression caused by the cardiopulmonary bypass (CBP). In this paper we evaluate the response to immunotherapy, with an extractive thymic hormone: thymostimulin at the dosage of 1 mg/kg/day; 20 patients of a group of 40 underwent CBP. Immunological monitoring was obtained with the "multitest CMI", a disposable skin test to evaluate changes of lymphocytes, especially T cells. Results shows a significant increase of response in patients treated with thymostimulin versus control. A larger sample and a deeper immunitary assessment will be provided in the future.

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Adjuvants, ImmunologicCardiopulmonary BypassHumansImmunity, CellularImmunocompromised HostMiddle AgedMonitoring, PhysiologicPostoperative ComplicationsThymus ExtractsClinical TrialEnglish AbstractJournal Article

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BibTeXRIS

M Maccherini, G Davoli, G Sani, F Miraldi, G Gotti, M Toscano. 1993. [Immunostimulation in heart surgery: thymostimulin. Preliminary data].. https://pubmed.ncbi.nlm.nih.gov/8177449/

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