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PubMed · 8180427

Multiple-stimulus method for rapid collection of auditory brainstem responses using high-frequency (> or = 8 kHz) tone bursts.

S A Fausti·C R Mitchell·R H Frey·J A Henry·J L O'Connor
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Abstract

Auditory brainstem responses (ABR) to high-frequency (> or = 8 kHz) tone-burst stimuli have shown potential for objective early detection of ototoxicity. In the case of ill, unresponsive, or otherwise difficult-to-test individuals, the patient group for whom this test is targeted, a threshold-seeking process can be too lengthy. A new method is described for obtaining responses to several high-frequency tone bursts in the same amount of time as that used in obtaining a single responses. Using 10 normal-hearing subjects, four high-frequency tone-burst stimuli (14, 12, 10, and 8 kHz) were presented singly, then in a multiple-stimulus sequence with onsets separated by 10 msec. Wave V response latencies from the multiple-stimulus sequences are compared to those presented singly, with small but statistically significant longer latencies observed for all stimuli following the initial stimulus (14 kHz) in the multiple sequence. Test-retest reliability was comparable between multiple and single conditions. These findings support the development of this technique for clinical auditory monitoring.

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Acoustic StimulationAdolescentAdultAnalysis of VarianceAuditory PerceptionEvoked Potentials, Auditory, Brain StemFemaleHumansMaleReaction TimeReproducibility of ResultsComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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S A Fausti, C R Mitchell, R H Frey, J A Henry, J L O'Connor. 1994. Multiple-stimulus method for rapid collection of auditory brainstem responses using high-frequency (> or = 8 kHz) tone bursts.. https://pubmed.ncbi.nlm.nih.gov/8180427/

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