The IRS-1 signaling system.

M F White

doi:10.1016/0959-437x(94)90090-6

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PubMed · 8193539

The IRS-1 signaling system.

M F White

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Abstract

IRS-1 is a principal substrate of the insulin receptor tyrosine kinase. It undergoes multi-site tyrosine phosphorylation and mediates the insulin signal by associating with various signaling molecules containing Src homology 2 domains. Interleukin-4 also stimulates IRS-1 phosphorylation, and it is suspected that a few more growth factors or cytokines will be added to form a select group of receptors that utilize the IRS-1 signaling pathway. More IRS-1-like adapter molecules, such as 4PS (IRS-2), may remain to be found.

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Amino Acid Sequence Animals Binding Sites Cell Division Humans Insulin Receptor Substrate Proteins Interleukin-4 Models, Biological Molecular Sequence Data Phosphoproteins Receptor, Insulin Signal Transduction Journal Article Research Support, U.S. Gov't, P.H.S.Review

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M F White. 1994. The IRS-1 signaling system.. https://doi.org/10.1016/0959-437x(94)90090-6

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