Clinical application of lung function testing in ventilated infants.

Abstract

Lung function (compliance, resistance and functional residual capacity), respiratory timing and ventilator-patient interaction can now be assessed in ventilator-dependent neonates. Such measurements have usually been made as part of research studies. Disease severity has been evaluated and prognosis predicted, the efficacy of many therapies, particularly surfactant, has been assessed by determining their ability to improve lung function. Measurement of ventilator-patient interaction has been particularly useful to refine conventional ventilation and in the development of newer forms of respiratory support such as patient triggered ventilation. The recent arrival of commercially available computerized lung function systems may tempt clinicians to introduce respiratory measurements into their practice. Before such an approach is adopted, however, it is vital the potential problems, limitations and likely benefits are carefully thought through.