PubMed · 8199351
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1994. Bibliographic update: nerve growth factor.. https://doi.org/10.1016/0955-2235(94)90021-3
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Four electrophoretically distinct alpha subunits can be isolated from mouse 7 S nerve growth factor protein (7 S NGF). It is proposed that each alpha subunit confers on its 7 S NGF species a different dissociation constant, and that the heterogeneity in dissociation constants of the different 7 S NGF species provide a mechanism for regulating the structure of betaNGF. A hypothesis that the different betaNGF structures have altered receptor affinities and/or physiological properties which can functionally differentiate NGF activity is also presented.
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