Sequential approach for describing channel opening and desensitization.

E Buchman; H Parnas

doi:10.1006/jtbi.1994.1077

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Sequential approach for describing channel opening and desensitization.

E Buchman·H Parnas

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Abstract

A formula describing the time-course of activation and desensitization of nicotinic-like acetylcholine channels is developed. The method used to arrive at this simplified formula is based on a sequential approach. Based upon this approximated and simple formula, analytical expressions for various specific experimental aspects are derived. These expressions together with the corresponding experiments provide a method to evaluate in a sequential manner the various rate constants involved.

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Acetylcholine Animals Computer Simulation Ion Channel Gating Mathematics Models, Chemical Time Factors Journal Article Research Support, Non-U.S. Gov't

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E Buchman, H Parnas. 1994-04-21. Sequential approach for describing channel opening and desensitization.. https://doi.org/10.1006/jtbi.1994.1077

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