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PubMed · 8216725

Development in the thymus: it takes two to tango.

M A Ritter·R L Boyd
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Abstract

Intrathymic T-cell development is dependent upon signals provided by the thymic stromal cell microenvironment. However, loss of thymic T cells in natural and experimentally induced situations is associated with a reduction in the surrounding epithelium, suggesting an interdependence between thymocytes and their microenvironment. Here, the authors review the evidence in favour of this intrathymic symbiosis, and hypothesize that T cells may provide maturation and survival signals that are necessary for the development and maintenance of their microenvironment.

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AnimalsCell DivisionCytokinesFemaleHumansMaleMiceMice, SCIDSignal TransductionT-LymphocytesThymus GlandJournal ArticleReview

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M A Ritter, R L Boyd. 1993. Development in the thymus: it takes two to tango.. https://doi.org/10.1016/0167-5699(93)90250-o

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