NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide.

C G Craig; T D White

doi:10.1016/0304-3940(93)90255-j

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PubMed · 8233091

NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide.

C G Craig·T D White

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Abstract

Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, L-arginine did not augment and L-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.

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Adenosine Animals Arginine Cerebral Cortex In Vitro Techniques Male N-Methylaspartate Nitric Oxide Nitroarginine Nitroprusside Rats Rats, Sprague-Dawley Journal Article

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C G Craig, T D White. 1993-08-20. NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide.. https://doi.org/10.1016/0304-3940(93)90255-j

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