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Brain-derived neurotrophic factor expression after long-term potentiation.

M Dragunow·E Beilharz·B Mason·P Lawlor·W Abraham·P Gluckman
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Abstract

Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.

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AnimalsBrainBrain-Derived Neurotrophic FactorDizocilpine MaleateEvoked PotentialsGene ExpressionIn Situ HybridizationLong-Term PotentiationMaleNerve Growth FactorsNerve Tissue ProteinsRNA, MessengerRatsRats, Sprague-DawleyJournal ArticleResearch Support, Non-U.S. Gov't

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M Dragunow, E Beilharz, B Mason, P Lawlor, W Abraham, P Gluckman. 1993-10-01. Brain-derived neurotrophic factor expression after long-term potentiation.. https://doi.org/10.1016/0304-3940(93)90420-p

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