[Cyclins A and B: redundancy and specificity].

D Wolowiec; M Ffrench

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PubMed · 8247635

[Cyclins A and B: redundancy and specificity].

D Wolowiec·M Ffrench

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Abstract

Mitotic cyclins constitute a regulatory subunit of the histone H1 kinase complex. On the basis of primary structure differences, they are divided into two classes, A and B. Both classes are necessary for mitosis to occur. Cyclins A and B differ in the timing of their cellular expression and in their affinity with the various members of the cdk (cyclin-dependent kinases) family. They also have specific functions: cyclin A plays a role in DNA replication, whereas cyclin B are involved in the inhibition of the fusion of early endosomes and in the activation of cdc25 phosphatase. Cyclins A and B can contribute to the development of neoplastic disorders, either directly (inappropriate expression of the cyclin A gene caused by the hepatitis B virus in hepatocellular carcinoma, interactions between cyclin A and factors involved in the regulation of cell division), or indirectly by causing phosphorylation of oncogene products by a cdk.

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CDC2 Protein Kinase CDC2-CDC28 Kinases Carcinoma, Hepatocellular Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinases Cyclins DNA Replication Hepatitis B Humans Liver Neoplasms Mitosis Protein Kinases Protein Serine-Threonine Kinases S Phase Simian virus 40 Tumor Virus Infections Journal Article Review

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D Wolowiec, M Ffrench. 1993. [Cyclins A and B: redundancy and specificity].. https://pubmed.ncbi.nlm.nih.gov/8247635/

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