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The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.

M D Habgood·G W Knott·K M Dziegielewska·N R Saunders
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Abstract

1. The blood-cerebrospinal fluid (CSF) exchange of a wide range of passively transported lipid insoluble compounds (0.43-5.4 nm molecular radius) has been investigated in rats at different stages of postnatal development (2 days old to adult). A novel 'litter-based' model for investigating blood-CSF barrier exchange in immature animals is described. 2. At each age investigated there was a clear inverse correlation between molecular radius and blood-CSF barrier exchange, in addition to an overall decrease in blood-CSF barrier exchange with increasing age. 3. The decrease in blood-CSF barrier exchange with age was not consistent with a reduction in pore diameters, nor does it appear to be due to an increase in the CSF sink effect with age. It seems likely to be due to a relative decrease in the number of a population of large diameter pores.

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AnimalsBiomarkersBlood-Brain BarrierBrainCerebrospinal FluidDiffusionImmunoglobulin GInulinModels, BiologicalPermeabilityRatsSolubilitySucroseJournal ArticleResearch Support, Non-U.S. Gov't

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M D Habgood, G W Knott, K M Dziegielewska, N R Saunders. 1993. The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.. https://doi.org/10.1113/jphysiol.1993.sp019760

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