Proteins regulating Ras and its relatives.

M S Boguski; F McCormick

doi:10.1038/366643a0

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Proteins regulating Ras and its relatives.

M S Boguski·F McCormick

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Abstract

GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and action. Their functions depend on their ability to alternate between inactive and active forms, and on their cellular localization. Numerous proteins affecting the GTPase activity, nucleotide exchange rates and membrane localization of Ras superfamily members have now been identified. Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.

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Amino Acid Sequence Animals Binding Sites GTP Phosphohydrolases GTPase-Activating Proteins Guanine Nucleotide Exchange Factors Guanine Nucleotides Humans Molecular Sequence Data Proteins Proto-Oncogene Proteins p21(ras)Transferases ras GTPase-Activating Proteins ras Guanine Nucleotide Exchange Factors Journal Article Review

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M S Boguski, F McCormick. 1993-12-16. Proteins regulating Ras and its relatives.. https://doi.org/10.1038/366643a0

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