PubMed · 82691
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1978-11-25. Medigoxin.. https://pubmed.ncbi.nlm.nih.gov/82691/
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The primary purpose of this study was to determine the relative usefulness of various measures to monitor body aluminum burden in weanling rats fed various amounts of aluminum (0.39 mumol Al/g diet for 29 days, approximately 40 mumol Al/g diet with or without citrate for 29 days and approximately 100 mumol Al/g diet with citrate for 12 or 29 days) or injected intraperitoneally with graded doses of aluminum (0.01, 4.6, 11.8, 23.5 or 94 mumol Al). Twenty-four hours prior to sacrifice, all rats were injected intraperitoneally with either desferrioxamine (75 mg DFO) or buffer. All seven indices of aluminum exposure monitored (i.e. tibia, liver, kidney and serum aluminum concentrations; changes in serum aluminum concentrations in response to DFO; urinary aluminum excretion with and without DFO treatment) were highly (P < 0.001) correlated to parenteral aluminum exposure. Five of these measures (i.e. tibia, liver and serum aluminum concentrations and urinary aluminum excretion with and without DFO treatment) were also highly (P < 0.001) correlated to oral aluminum loads. Changes induced by DFO were very small. Moreover, the 'DFO stimulated' serum and urine aluminum concentrations were not more correlated to the body load of aluminum, as indicated by tibia aluminum concentrations, than baseline values. Comparisons of aluminum exposure in tibias and sera of rats exposed to parenteral and oral aluminum indicated that only 0.01-0.04% of dietary aluminum was absorbed. Ingestion of citrate had small but significant effects on aluminum retention.
OBJECTIVE: To study systemic absorption of glycine irrigation solution and its consequences during transcervical endometrial resection (TCER). DESIGN, SETTING, PATIENTS: A prospective study of 20 consecutive female patients who underwent elective TCER in a teaching hospital. METHOD: During the operation, patients were monitored with electrocardiography, automated oscillotonometry, pulse oximetry, capnography and a central venous pressure recorder. Plasma sodium and potassium levels were measured at 15-minute intervals. Blood haemoglobin concentration, serum osmolality, and plasma sodium, potassium and glycine concentrations were measured before and after surgery. RESULTS: Plasma glycine concentration increased in all patients after TCER. The highest concentration recorded was 5575 mumol/L. The increase correlated only with the maximum intraoperative decrease in plasma sodium, which was 7 mmol/L in two patients whose plasma glycine level increased by 3001 mumol/L and 5335 mumol/L. CONCLUSION: Systemic absorption of glycine irrigation solution occurred in all patients during TCER. Serial measurement of plasma sodium was necessary to detect this complication. A decrease in plasma sodium level by 7 mmol/L or more during surgery would indicate fluid absorption that could cause severe hyperglycinaemia and other potential complications.
Rat vascular anastomosis was performed using a newly synthesized bioabsorbable material (LA-GA copolymer) cuffs and the ordinary polyethylene cuffs. The LA-GA copolymer cuff which anastomosed the portal vein and the inferior vena cava were patent and developed no collateral veins even after 6 months, keeping the transplanted liver normal. By contrast, the polyethylene cuff anastomosed portal vein was completely occluded and the collateral veins were highly developed, with the transplanted liver showing the fatty degeneration of hepatocytes and numerous regenerative nodules. It is concluded that the LA-GA copolymer cuff is a suitable material for the short and long term study of rat orthotopic liver transplantation.