Chromatin structure: mapping proteins associated with genomic DNA using crosslinking.

A D Mirzabekov

doi:10.1016/0378-1119(93)90055-8

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Chromatin structure: mapping proteins associated with genomic DNA using crosslinking.

A D Mirzabekov

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Abstract

The structure and structural dynamics of chromatin and nucleosomes in transcription and replication were studied by DNA-protein crosslinking. A general strategy has been designed and a number of methods have been developed to map proteins bound to the genomic DNA, to sequence the arrangement of such proteins along DNA in multi-protein complexes, and to identify interacting nucleotides and amino acid residues. Perspectives for large-scale mapping of proteins associated with genomic DNA are discussed.

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Amino Acid Sequence Chromatin Cross-Linking Reagents DNA DNA-Binding Proteins Molecular Sequence Data Journal Article Review

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A D Mirzabekov. 1993-12-15. Chromatin structure: mapping proteins associated with genomic DNA using crosslinking.. https://doi.org/10.1016/0378-1119(93)90055-8

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