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PubMed · 8281132

Complexity of protein folding.

A S Fraenkel
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Abstract

It is believed that the native folded three-dimensional conformation of a protein is its lowest free energy state, or one of its lowest. It is shown here that both a two- and three-dimensional mathematical model describing the folding process as a free energy minimization problem is NP-hard. This means that the problem belongs to a large set of computational problems, assumed to be very hard ("conditionally intractable"). Some of the possible ramifications of this result are speculated upon.

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DNAMathematicsModels, TheoreticalNucleic Acid ConformationProtein ConformationProtein FoldingProteinsJournal Article

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A S Fraenkel. 1993. Complexity of protein folding.. https://doi.org/10.1007/bf02460704

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