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Weak male-driven molecular evolution in rodents.

B H Chang·L C Shimmin·S K Shyue·D Hewett-Emmett·W H Li
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Abstract

In humans and rodents the male-to-female ratio of mutation rate (alpha m) has been suggested to be extremely large, so that the process of nucleotide substitution is almost completely male-driven. However, our sequence data from the last intron of the X chromosome-linked (Zfx) and Y chromosome-linked (Zfy) zinc finger protein genes suggest that alpha m is only approximately 2 in rodents with a 95% confidence interval from 1 to 3. Moreover, from published data on oogenesis and spermatogenesis we estimate the male-to-female ratio of the number of germ cell divisions per generation to be approximately 2 in rodents, confirming our estimate of alpha m and suggesting that errors in DNA replication are the primary source of mutation. As the estimated alpha m for rodents is only one-third of our previous estimate of approximately 6 for higher primates, there appear to be generation-time effects--i.e., alpha m decreases with decreasing generation time.

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AnimalsBase SequenceBiological EvolutionDNADNA ReplicationFemaleGenetic LinkageHumansIntronsMaleMiceMice, Inbred BALB CMolecular Sequence DataRatsRats, Inbred F344Sequence Homology, Nucleic AcidSex CharacteristicsX ChromosomeY ChromosomeZinc FingersJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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B H Chang, L C Shimmin, S K Shyue, D Hewett-Emmett, W H Li. 1994-01-18. Weak male-driven molecular evolution in rodents.. https://doi.org/10.1073/pnas.91.2.827

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