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PubMed · 8296110

Two-stage sampling in pharmaceutical applications.

J Shao·S C Chow
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Abstract

In the pharmaceutical industry, some tests for quality assurance before, during and after the manufacture of a drug product involve a two-stage sampling technique. We propose statistical testing procedures in a two-stage sampling problem with large within-class sample sizes. We also derive a two-stage sampling plan by minimizing the expected squared volume (or the generalized variance) of the confidence region related to the test. We present two examples to illustrate the proposed methods.

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Clinical Trials as TopicContraceptives, Oral, CombinedContraceptives, Oral, SyntheticDose-Response Relationship, DrugDrug CombinationsDrug EvaluationDrug IndustryDrug PackagingEthinyl EstradiolFemaleHumansMaterials TestingMulticenter Studies as TopicNorethindroneQuality Assurance, Health CareQuality ControlJournal Article

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J Shao, S C Chow. 1993-11-15. Two-stage sampling in pharmaceutical applications.. https://doi.org/10.1002/sim.4780122104

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