Delayed hypersensitivity, immune deviation, antigen processing and T-cell subset selection in syphilis pathogenesis and vaccine design.

S Sell; P L Hsu

doi:10.1016/0167-5699(93)90196-r

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Delayed hypersensitivity, immune deviation, antigen processing and T-cell subset selection in syphilis pathogenesis and vaccine design.

S Sell·P L Hsu

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Abstract

T-cell mediated delayed-type hypersensitivity (DTH) is the predominant immune mechanism for clearing tissues of infecting organisms in the primary lesion of syphilis. Here, Stewart Sell and Pei-Ling Hsu propose a strategy for vaccination against syphilis in which selective induction of DTH may be accomplished by using BCG vectored vaccines containing selected DNA sequences for T. pallidum antigens.

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Animals Antigen Presentation Antigens, Bacterial Bacterial Vaccines Base Sequence Humans Hypersensitivity, Delayed Molecular Sequence Data Mycobacterium bovis Syphilis T-Lymphocyte Subsets Treponema pallidum Vaccines, Synthetic Journal Article Review

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S Sell, P L Hsu. 1993. Delayed hypersensitivity, immune deviation, antigen processing and T-cell subset selection in syphilis pathogenesis and vaccine design.. https://doi.org/10.1016/0167-5699(93)90196-r

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