Beta camera low activity tumor imaging.

K Ljunggren; S E Strand; C P Ceberg; H Sjöholm; D Elmqvist; A Brun; L G Salford

doi:10.3109/02841869309096148

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Beta camera low activity tumor imaging.

K Ljunggren·S E Strand·C P Ceberg·H Sjöholm·D Elmqvist·A Brun·L G Salford

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Abstract

A new technique, the beta camera, to complement film autoradiography, with fast quantitative imaging of beta particle-emitting radionuclides has been developed. It consists of a thin plastic scintillator and a light-sensitive microchannel plate detector. The thin tissue sample is mounted on the scintillator. Our first system had a high background and a moderate spatial resolution of 900 microns. We now report an improved system with a photomultiplier tube mounted on the scintillator of the microchannel plate detector. Only events registered by both detectors are accepted. A fast coincidence unit processes the signals, and if a time overlap exists, an event is generated in the beta camera. In the coincidence mode, images with low activity distribution of 201Tl (count rate 1 s-1) in 50 microns-thick slices of a human glioma tumor could be recorded with a spatial resolution of 500 microns.

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Brain Neoplasms Carbon Radioisotopes Gamma Cameras Glioma Humans Models, Structural Radionuclide Imaging Scintillation Counting Thallium Radioisotopes Tissue Distribution Journal Article Research Support, Non-U.S. Gov't

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K Ljunggren, S E Strand, C P Ceberg, H Sjöholm, D Elmqvist, A Brun, L G Salford. 1993. Beta camera low activity tumor imaging.. https://doi.org/10.3109/02841869309096148

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