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PubMed · 8312552

[The capacity of Yersinia pestis toxin to decrease the functional response of human thrombocytes to stimulation by hormones].

T D Cherkasova·V N Bochkov·V A Iurkiv·V I Pokrovskiĭ
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Abstract

Yersinia pestis toxin (fraction II by E. Baker) (YPT) inhibited the aggregation of human platelets as well as elevation of [Ca2+], induced by different agonists (ADP, PAF, Thrombin). Agonist-induced Ca2+ mobilization and Ca2+ influx were dose-dependently inhibited by the toxin. The effect was rapid, developing during the first minute of incubation with toxin. In contrast to murine lethal protein (MLP), the platelet-inhibiting activity was thermostable and was eliminated in the course of MLA purification from YPT. These data indicate that Yersinia pestis component, unlike MLP, could influence the Ca(2+)-dependent processes in human platelets.

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Adenosine DiphosphateBacterial ToxinsBlood PlateletsCalciumDepression, ChemicalDose-Response Relationship, DrugHumansPlatelet AggregationPlatelet Aggregation InhibitorsStimulation, ChemicalTime FactorsYersinia pestisJournal Article

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T D Cherkasova, V N Bochkov, V A Iurkiv, V I Pokrovskiĭ. 1993. [The capacity of Yersinia pestis toxin to decrease the functional response of human thrombocytes to stimulation by hormones].. https://pubmed.ncbi.nlm.nih.gov/8312552/

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