CDw50 and ICAM-3: two names for the same molecule.

M Juan; R Vilella; J Mila; J Yagüe; A Miralles; K S Campbell; R J Friedrich; J Cambier; J Vives; A R De Fougerolles

doi:10.1002/eji.1830230717

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CDw50 and ICAM-3: two names for the same molecule.

M Juan·R Vilella·J Mila·J Yagüe·A Miralles·K S Campbell·R J Friedrich·J Cambier·J Vives·A R De Fougerolles

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Abstract

CDw50 differentiation antigen is a molecule broadly expressed on hematopoetic cells but not on other cells. Previous experiments showed that CDw50 monoclonal antibodies (mAb) inhibited primary mixed lymphocyte culture (MLC). To understand the function of CDw50 better, we purified it and obtained peptide sequence. At the same time, intercellular adhesion molecule (ICAM)-3, the third ligand of lymphocyte function-associated molecule 1, was described by mAb and subsequent cDNA cloning. Immunochemical, functional, and protein sequencing studies show that ICAM-3 and CDw50 are the same glycoprotein, a 120-kDa surface molecule with presumably an important role in the immune responses.

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Amino Acid Sequence Antibodies, Monoclonal Antigens, CD Antigens, Differentiation Cell Adhesion Molecules Cloning, Molecular Humans Molecular Sequence Data Peptides Sequence Alignment Transfection Comparative Study Journal Article Research Support, Non-U.S. Gov't

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M Juan, R Vilella, J Mila, J Yagüe, A Miralles, K S Campbell, R J Friedrich, J Cambier, J Vives, A R De Fougerolles. 1993. CDw50 and ICAM-3: two names for the same molecule.. https://doi.org/10.1002/eji.1830230717

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