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PubMed · 8325745

Atopic ocular disease.

N P Barney·C S Foster
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Abstract

Atopy arises from a complex interplay between immunogenetic controls and complex environmental allergens. Family studies of atopic patients indicate a polygenic control of IgE production overlayed with exposure to certain ubiquitous environmental antigens. Ultrapurified antigen studies in families indicate that HLA-D immune response genes, notably HLA-DR/Dw2, are implicated in some atopic responses. IgE-binding factors and gene regulation of proteins controlling glycosylation of them also influence the serum levels of IgE, as do the levels of at least two cytokines, IL-4 and gamma interferon.

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AllergensConjunctivitis, AllergicGenes, MHC Class IIHLA-DR AntigensHumansHypersensitivity, ImmediateImmunoglobulin EJournal ArticleReview

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BibTeXRIS

N P Barney, C S Foster. 1993. Atopic ocular disease.. https://doi.org/10.1097/00004397-199303320-00009

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