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Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.

D Fukushima·M Konishi·K Maruyama·T Miyamoto·S Ishiura·K Suzuki
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Abstract

The activation of the secretory pathway for the amyloid protein precursor (APP) by phorbol 12-myristate 13-acetate in human glioblastoma A-172 cells leads to a decrease in intracellular beta-amyloidogenic fragments derived from APP. The result suggests that a metabolic switch of APP from the endosomal/lysosomal pathway to a secretion route occurs after PMA treatment.

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1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAlkaloidsAmyloid beta-Protein PrecursorAnimalsCell LineGliomaHumansIsoquinolinesKineticsMolecular WeightPeptide FragmentsPiperazinesProtein Kinase CProtein Kinase InhibitorsRecombinant ProteinsStaurosporineTetradecanoylphorbol AcetateTransfectionTumor Cells, CulturedJournal Article

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D Fukushima, M Konishi, K Maruyama, T Miyamoto, S Ishiura, K Suzuki. 1993-07-15. Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.. https://doi.org/10.1006/bbrc.1993.1804

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