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PubMed · 8333967

PROBE: a computer program employing an integrated neural network approach to protein structure prediction.

S R Holbrook·I Dubchak·S H Kim
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Abstract

A computer program, PROBE, has been designed for the prediction of protein structural features from amino acid sequence. This program integrates a variety of computer-simulated neural networks, each predicting an aspect of protein structure, into a single, easy-to-use package. The surface accessibility of each residue, the presence of disulfide bonds, the overall secondary structure composition and the residue secondary structures, including beta-turn type, are predicted. In addition, the overall amino acid composition and relative hydrophobicity are used to determine whether a protein belongs to one of four common folding motifs. PROBE is able to compare and synergistically improve the predictions by allowing communication between the different networks.

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Amino Acid SequenceMolecular Sequence DataNeural Networks, ComputerProtein Structure, SecondarySoftwareTechnical ReportJournal Article

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S R Holbrook, I Dubchak, S H Kim. 1993. PROBE: a computer program employing an integrated neural network approach to protein structure prediction.. https://pubmed.ncbi.nlm.nih.gov/8333967/

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