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Gliosarcoma with features of chondroblastic osteosarcoma.

K Hayashi·N Ohara·H J Jeon·S Akagi·K Takahashi·T Akagi·S Namba
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Abstract

BACKGROUND: The occurrence of osteoid-chondral elements in gliosarcoma is extremely rare and has been reported in only two cases. A new, rare case of gliosarcoma with osteosarcomatous differentiation in a 55-year-old man and histogenesis of osteoid-chondral tissue in gliosarcoma is discussed. METHODS: Surgically removed tumor tissues were examined immunohistochemically and electron microscopically, and a histologic examination was performed. RESULTS: Immunohistochemical and electron microscopic studies confirmed the presence of glial, fibroblastic, and osteoid-chondral elements. A major part of the sarcomatous tissue was undifferentiated and stained only by vimentin. Some areas of osteoid-chondral tissue were positive for glial fibrillary acidic protein (GFAP). CONCLUSIONS: These data suggest that osteoid-chondral elements came from the sarcomatous portion and GFAP positivity is not restricted to astrocytes and has been seen particularly in chondroid areas of non-glial tumors.

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Brain NeoplasmsCell Transformation, NeoplasticChondroblastomaFrontal LobeGlial Fibrillary Acidic ProteinGliomaHumansMaleMiddle AgedOsteosarcomaCase ReportsJournal Article

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K Hayashi, N Ohara, H J Jeon, S Akagi, K Takahashi, T Akagi, S Namba. 1993-08-01. Gliosarcoma with features of chondroblastic osteosarcoma.. https://doi.org/10.1002/1097-0142(19930801)72%3A3%3C850%3A%3Aaid-cncr2820720334%3E3.0.co%3B2-4

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