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Transmembrane signalling through the T-cell-receptor-CD3 complex.

B Malissen·A M Schmitt-Verhulst
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Abstract

Recent data support the existence of activation motifs within different subunits of the T-cell-receptor-CD3 complex. This architecture generates a receptor composed of discrete modules, each capable of being coupled to an effector pathway. Although new T-cell specific protein tyrosine kinases have recently been identified, the nature of the proximal non-receptor protein tyrosine kinase linking the T-cell receptor complex to essential signalling effectors remains unknown. Developmentally regulated differences in T-cell-receptor-CD3 assembly or stability may lead to the expression of isoforms displaying different sets of activation motifs. Whether this may be the basis of differential signalling during T-cell development is still a matter of speculation.

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Amino Acid SequenceAnimalsCell DifferentiationConsensus SequenceGene Expression RegulationLymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)Macromolecular SubstancesMembrane ProteinsModels, MolecularMolecular Sequence DataPhosphorylationProtein Processing, Post-TranslationalProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-fynReceptor-CD3 Complex, Antigen, T-CellReceptors, AntigenReceptors, Antigen, T-CellReceptors, FcSignal TransductionT-LymphocytesJournal ArticleReview

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B Malissen, A M Schmitt-Verhulst. 1993. Transmembrane signalling through the T-cell-receptor-CD3 complex.. https://doi.org/10.1016/0952-7915(93)90049-x

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