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Analytical approaches to genomic evolution.

D Sankoff
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Abstract

We model the non-local mechanisms of genomic evolution and propose methods for studying the evolutionary divergence of species based on these models. Mechanisms include the movement of segments of genomes within a single chromosome (transpositions), the reciprocal translocation of segments between two chromosomes, and the inversion of segments. Each of these is studied in the context of a different type of genomic data. We introduce the theory of phylogenetic invariants for evolutionary inference based on very long macromolecular sequences.

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AnimalsBiological EvolutionDNA, MitochondrialGenomeHumansMiceMitochondriaModels, GeneticMutationPhylogenySequence Analysis, DNATranslocation, GeneticComparative StudyJournal ArticleReview

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D Sankoff. 1993. Analytical approaches to genomic evolution.. https://doi.org/10.1016/0300-9084(93)90174-q

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