PubMed · 8349081
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J Delamarre. 1993. [Sic transit].. https://pubmed.ncbi.nlm.nih.gov/8349081/
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An approach based on disposition decomposition analysis (DDA) and the hysteresis minimization principle has been developed for pharmacodynamic modeling. It allows calculation of the mean transit time and the ratio of distribution clearance to biophase distribution volume of drug, and determination of the drug concentration-time function at the biophase (Cb(t)). The proposed method extends the DDA approach to drug distribution to a possibly heterogeneous effect compartment of a generalized pharmacokinetic/pharmacodynamic model. The application of this DDA-dynamics method is demonstrated using published data for pancuronium.
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Advances in medical and surgical technique and the development of home parenteral nutrition have led to an increasing number of patients with short-bowel syndrome. Many patients could benefit from definite surgical therapy as long-term parenteral nutrition besides being expensive frequently causes severe complications. Various techniques to prolongate intestinal transit and increase the absorptive area of the remaining small bowel have been experimentally developed and some have been successfully employed in humans. The recent discovery of new potent immunosuppressive agents has initiated clinical endeavours at intestinal transplantation. The various techniques for the surgical therapy of short-bowel syndrome with their indications and potential risks are reviewed.