Wilms' tumour gene and function.

N D Hastie

doi:10.1016/0959-437x(93)90113-4

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Wilms' tumour gene and function.

N D Hastie

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Abstract

The Wilms' tumour gene, WT1, encodes a protein with four zinc fingers that is probably a transcription factor. In humans, WT1 mutations can lead to childhood kidney tumours and to developmental defects of the kidney and gonad. The WT1 gene may have a role in the mesenchyme to epithelial switch in a range of mesodermally derived tissues. Furthermore, growth-factor genes may be targets for repression by the WT1 protein during development. WT1 is the first example of a tumour-suppressor gene with a specific developmental role.

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Animals DNA-Binding Proteins Genes, Wilms Tumor Humans WT1 Proteins Zinc Fingers Journal Article Research Support, Non-U.S. Gov't Review

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N D Hastie. 1993. Wilms' tumour gene and function.. https://doi.org/10.1016/0959-437x(93)90113-4

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