Ventricular remodelling: consequences and therapy.

H N Sabbah; S Goldstein

doi:10.1093/eurheartj/14.suppl_c.24

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PubMed · 8365425

Ventricular remodelling: consequences and therapy.

H N Sabbah·S Goldstein

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Abstract

The mammalian left ventricle can change its size and shape in response to a variety of stimuli including loss of tissue and external work. These changes in size and shape, defined as remodelling, are the sum total of a number of processes that involve the myocyte and the interstitial fibrous structures which provide the matrix in which the myocyte functions. The adapted mechanisms which occur are affected by humoral and cellular phenomena and can be modified by pharmacological agents. This paper reviews the remodelling process that occurs in myocardial infarction and heart failure and the effect of various pharmacological agents on this remodelling process.

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Adaptation, Physiological Angiotensin-Converting Enzyme Inhibitors Cardiac Output, Low Extracellular Matrix Heart Ventricles Humans Hypertrophy, Left Ventricular Myocardial Infarction Myocardium Journal Article Review

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H N Sabbah, S Goldstein. 1993. Ventricular remodelling: consequences and therapy.. https://doi.org/10.1093/eurheartj%2F14.suppl_c.24

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