Is airways hyperreactivity selective or non-selective?

R Djukanović

doi:10.1007/978-3-0348-7324-6_20

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Is airways hyperreactivity selective or non-selective?

R Djukanović

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Abstract

Airways hyperresponsiveness has often been termed "nonspecific" on account of close correlations between responses to histamine and methacholine. This relationship, however, does not apply to stimuli, such as exercise, hyperventilation, sulphur dioxide, and distilled water. We have shown that allergen causes a greater and more prolonged increase in responses to bradykinin than to methacholine adding support to the notion that airways hyperresponsiveness is a selective pathophysiologic abnormality.

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Allergens Asthma Bronchial Hyperreactivity Bronchoconstrictor Agents Histamine Humans Methacholine Chloride Journal Article Review

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R Djukanović. 1993. Is airways hyperreactivity selective or non-selective?. https://doi.org/10.1007/978-3-0348-7324-6_20

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