Sexual differences in sensitivity to methamphetamine toxicity.

G C Wagner; T L Tekirian; C T Cheo

doi:10.1007/bf01244939

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Sexual differences in sensitivity to methamphetamine toxicity.

G C Wagner·T L Tekirian·C T Cheo

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Abstract

Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.

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Animals Corpus Striatum Dopamine Female Male Methamphetamine Mice Mice, Inbred Strains Nervous System Sex Characteristics Journal Article

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G C Wagner, T L Tekirian, C T Cheo. 1993. Sexual differences in sensitivity to methamphetamine toxicity.. https://doi.org/10.1007/bf01244939

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